Case Studies
GENEFLAMMATION
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Real Results · Real Biology

Patient
Case Studies

Detailed, long-form accounts of real patient transformations — the genomic findings, the protocols, and the results.

Names anonymized. Results may vary. Not medical advice.

Chronic Fatigue & Inflammation
👤 Margaret T., 54📖 11 min read

From Exhausted to Optimized: How Margaret Finally Got Her Energy Back

After 8 years of unexplained fatigue and failed treatments, Margaret's genomic blueprint revealed a triple hit — MTHFR, SOD2, and NF-κB variants — driving her chronic inflammation.

MTHFR C677TSOD2 Ala16ValNFKB1 rs28362491
Before
✕ Chronic fatigue rated 8/10 — requiring 10+ hours of sleep with no relief
✕ Elevated CRP at 4.2 mg/L (high-normal range) for 3 consecutive years
After the Protocol
✓ Fatigue dropped to 2/10 — sleeping 7.5 hours and waking refreshed
✓ CRP normalized to 0.6 mg/L — a 6x reduction
Neuroinflammation & Cognitive Decline
👤 David R., 47📖 13 min read

Reversing Brain Fog: David's Neuroinflammatory Turnaround at 47

A high-performing attorney experiencing cognitive decline and mood instability. His genomic profile revealed a perfect storm of neuroinflammatory risk that conventional psychiatry had completely missed.

COMT Val158MetTNF-α rs1800629APOE ε3/ε4MAO-A uVNTR
Before
✕ Cognitive performance declining — word retrieval, working memory, focus all impaired
✕ Mood instability: cycling between irritability and low motivation
After the Protocol
✓ Cognitive performance self-rated returned to 'baseline from 10 years ago'
✓ Mood stable — no significant cycling in final 6 weeks of protocol
Hormonal Imbalance & Metabolic Dysfunction
👤 Sofia M., 38📖 10 min read

The Weight That Wouldn't Move: Sofia's Metabolic Reset

Three years of clean eating and consistent exercise with no fat loss. Sofia's genomic profile uncovered why — and a targeted protocol achieved what years of effort couldn't.

FTO rs9939609PPARG Pro12AlaCYP1B1 Leu432ValCOMT Val158Met
Before
✕ Zero net fat loss over 36 months despite consistent diet and exercise
✕ Estrogen dominance symptoms: bloating, mood swings, heavy cycles
After the Protocol
✓ Lost 18 lbs — first significant fat loss in over three years
✓ Estrogen dominance symptoms resolved by week 6